Sense transcription through the S region is essential for immunoglobulin class switch recombination
نویسندگان
چکیده
منابع مشابه
Sense transcription through the S region is essential for immunoglobulin class switch recombination.
Class switch recombination (CSR) occurs between highly repetitive sequences called switch (S) regions and is initiated by activation-induced cytidine deaminase (AID). CSR is preceded by a bidirectional transcription of S regions but the relative importance of sense and antisense transcription for CSR in vivo is unknown. We generated three mouse lines in which we attempted a premature terminatio...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189
DOI: 10.1038/emboj.2011.56